Folic Acid prescribing information |
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Folic acid
1. Description: Folic acid, also known as folate, is a B-vitamin that can be found in some enriched foods and vitamin pills. If women have enough of it in their bodies before pregnancy, this vitamin can decrease the risk for neural tube defects (NTDs), which are birth defects of the baby's brain or spine. The U.S. Public Health Service recommended in September 1992 that all women of childbearing age consume 400 micrograms (ug) of folic acid daily to reduce their risk of having a pregnancy affected with spina bifida or other neural tube defects.
2. Folic acid is Prescribed for: In recent years, doctors have come to realize that folic acid is very important for everyone in maintaining health. It has long been known that folic acid plays an important role in the production of normal red blood cells. More recent studies suggest that folic acid may help prevent heart disease, stroke and certain cancers, especially colon cancer. While these studies have not proven a protective effect, they suggest that many people may benefit from taking folic acid.
3. Drug Mechanism: Folic acid enhances chemical reactions that contribute to the production of red blood cells, the manufacture of DNA needed for cell replication, and the metabolism of amino acids (compounds necessary for the manufacture of proteins).
4. Dosage Form: The best way to get enough folic acid is to take a multivitamin with 400 micrograms of folic acid in it and eat a healthy diet. Most multivitamins have this amount, but check the label to be sure. You also can get folic acid in your diet, but it's hard to get enough every day through food alone. That's why the March of Dimes encourages all women of childbearing age to take a multivitamin containing folic acid every day as part of a healthy diet.
5. Drug Interactions: Folic acid antagonists, which include such common drugs as trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase the risk not only of neural-tube defects, but also of cardiovascular defects, oral clefts, and urinary tract defects.
6. Pregnancy: Folic acid supplementation is recommended during pregnancy.
7. Nursing Mothers: Folic acid supplementation is recommended while nursing.
8. Dietary and Alcohol Considerations: Alcohol impairs the body's utilization of folic acid; avoid it completely if you are taking folic acid.
9. Possible Side Effects: Folate has been tolerated without significant side effects in dosages as high as 250 mg and 1,000 mg/day. However, some scientists reported malaise, sleep problems, irritability, and an increased activity level when folate was given to normal, healthy volunteers. Folate has been reported to exacerbate the frequency of seizures in epilepsy, but we have not experienced this problem in patients with FXS and seizures. Folate treatment should be avoided, however, in patients with poorly controlled seizures. Folate may occasionally cause loose stools and can prolong diarrhea in children recovering from gastroenteritis. If diarrhea occurs, the dose of folate should be lowered or discontinued until the diarrhea resolves. We reported vitamin B6 deficiency in males with FXS taking 10 mg of folic acid per day. To avoid this problem, patients should take daily a multiple vitamin with B6 while on folic acid therapy. Folate can also interfere with zinc absorption in the intestine, and serum zinc levels should therefore be monitored at least once a year.
10. Storage: Keep this medication in the container it came in, tightly closed, and out of reach of children. Capsules should be stored at room temperature (77°F (25°C)) and away from excess heat and moisture (not in the bathroom). It is okay for brief periods in temperatures between 59-86°F (15-30°C). Throw away any medication that is outdated or no longer needed.
11. Package Size and Type: Tablets: 3 mg.
12. Where can I get more information on Foloc acid?
a) U.S. National Library of Medicine and National Institutes of Health
b) WebMD Corporation
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
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Folic Acid notes:
Folic Acid is an important medication that helps in production of normal red blood cells. Folic acid B12, folic acid B6, folic acid B5 are some of the popular terms associated with folic acid. Thus Folic Acid nutrition is considered vital for women of conception age. Intake of adequate vitamin Folic Acid during pre-conception period and pregnancy reduces the risk of congenital malformations including neural tube defects, congenital heart defects, cleft lip, limb defects and urinary tract anomalies in the developing foetus. Besides being a boon to pregnant women, Folic Acid may also prevent heart disease, stroke and certain cancers. Zinc Folic Acid or taking zinc supplements along with Folic Acid has helped increase sperm count in men and thus improved their fertility.
Normally one would not find much Folic Acid symptoms due to consumption of Folic Acid. Folsav or Folic Acid can cause side effects like depression, sleep disorders, mood fluctuations aggravate epilepsy or cause loose stools or diarrhoea in children.
Alcohol consumption should be completely avoided during usage of Folic Acid as it restricts body’s capacity to utilize Folic Acid. Generally it is recommended to take a multivitamin consisting of 400 mg of Folic Acid along with a balanced diet. Especially women of childbearing age should make it a practice to take multivitamin with 400 mg Folic Acid or more daily as prescribed by their physician that would help them having normal and healthy baby later. Consuming high folic acid foods like leafy green vegetables, beans and legumes, citrus foods, fortified cereal products and liver products sources Folic Acid to body.
Anti-Agig news:
Effects of age and caloric restriction are different in mouse ovaries and testicles.
Researchers from National institute on aging, Baltimore have found that ovaries age faster than testis. The effects of caloric restriction(CR) are different in somatic tissues and gonads and there is decrease in ovary function while testicles have little effect.
In the experiment, whole genome DNA was examined by microarrays to find the effect of age, sex and diet on gene expression in testicles and ovaries of mice. Out of six pair of genes responsible for aging in muscle, only kidney and brain were associated with aging in ovaries and none in testicles. There was a major alteration of gene expression patterns in ovary between 6 and 16 months which corresponds to the time when ovulation ceases in mice while the gene expression of testicles show little change between oldest and youngest mice.
CR effects on gene expression on ovary are down regulation of ovary function specific genes by showing a decrease of metabolism and follicle growth in young females. In contrast, testicles showed expression patterns different from ovary. The majority of genes regulated by CR were testicles function associated, a reverse to that of ovaries suggesting that there is no tendency to sacrifice testicular functions under a CR diet. Thus, the males tend to invest more energy in reproduction in CR conditions.
It can be explained due to the fact that the females need nutrition to nurture the offspring and during the times of food shortage there is decrease in ovary function to prevent dangers of food shortage.
Folic Acid review article...
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Antioxidants and Vitamines
 Folic Acid prescribing information
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