Cozaar prescribing information |
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Full prescription information or package insert for Cozaar
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Cozaar notes:
Losartan is a widely used medicine for treatment of high blood pressure which is sold under the product brand name Cozaar. It can be taken alone or in tandem with other medicines like diuretics to keep high blood pressure under control. Being first of an emerging class of medications called angiotensin II receptor antagonists; Cozaar averts the constriction of blood vessels by keeping angiotensin II hormone under check. Progress of kidney disease caused by Type 2 diabetes slows down under the effect of Cozaar.
Regular use of Cozaar is essential and it may take several weeks of medication before the desired results are obtained. As the medicine only keeps high blood pressure under control and does not cure it, it becomes pertinent that patient should continue taking Cozaar even after he starts feeling absolutely fine.
Though it can be taken with or without food, Cosaar should be taken at the same time every day to establish a routine. It is best to sore the drug in an airtight jar away from sunlight at room temperature.
It’s quite difficult to anticipate side effects and doctor should be informed as soon as any change is noticed in intensity. Cough, dizziness, upper respiratory tract infection are some of the more common side effects. Less frequent side effects include diarrhea, indigestion, insomnia, muscle cramps or pain, swelling of face, lips, throat and tongue, nasal congestion, and other allergic reactions.
Since Cozaar is known to be potentially fatal for the unborn child, it’s important to stop taking the drug as soon as pregnancy becomes known. It affects infants adversely so breast feeding mothers should either avoid Cozaar or if it is essential for their health, stop feeding the baby.
As it’s not clear how the patient would react to Cozaar, he should avoid driving and operating machinery by himself in the first few days of starting medication.
2010 Jul 15. [Epub ahead of print]
Lambers Heerspink HJ et all.
Differentiation between urinary protein excretion for predicting renal events
2010 May 12;5:CD006872.
Wang H et all.
In order to stop development of diabetic kidney disease use prostagladin E1
2010 Mar 2. [Epub ahead of print]
El Desoky ES.
Usage of drug therapy for heart diseases an important view
2009 Dec;2(4):483-92. Epub 2009 Oct 1.
Marian AJ.
Inventional therapies in hypertrophic cardiomyopathy
2009 Dec;11(6):456-62.
Pinto R, Gradman AH.
Straight and forwarded renin inhibition
2009 Sep 13. [Epub ahead of print]
Xu F et all.
Heart diseases related to losartan and its subsequent medical application
2008 Nov;16(11):382-6.
Mulder BJ.
Marfan syndrome relative to distal aorta
2008 Nov;6(10):1343-6.
Ferri C et all.
Adverse effects of anti-hypertensive therapies
2008 Jun;10(2):118-22.
Shrestha B, Dhungel S, Pahari SK.
Department of Internal Medicine/Cardiology, Nepal Medical College Teaching Hospital, Attarkhel, Jorpati, Kathmandu, Nepal. balaramshresthajsps@yahoo.com
Ambulatory blood pressure monitoring: a useful tool to diagnose hypertension and supervise it's treatment.
2007 Nov;30(11):1119-28.
Yao EH et all.
Losartan – an important and effective medicine that accelerates the on-going function of endothenil progenitor cells
2007 Oct;2:7-12.
Narkiewicz K.
Hypertension patients cases reveals differentiation between home and office blood pressure with losartan
2007 Sep;30(9):831-7.
Shimosawa T et all.
Losartan vs candesartan in hypertension therapies
Hypertens Res. 2007 Jan;30(1):49-53.
Bahadir O et all.
Yelmisartan and losartan on insulin resistance in hypertensive patients
Effectiveness of telmisartan and losartan on insulin resistance: a study in hypertensive patients with metabolic syndrome.
Ren Fail. 2007;29(4):441-6.
Horita Y et all.
Prednisolone administered with losartan provide renoprotection
Renoprotection in patients with IgA nephropathy can be conferred by using prednisolone along with losartan.
Diabetes Care. 2006 Oct;29(10):2210-2217.
Winkelmayer WC et all.
Efficacy of Angiotensin II Receptor Blockade
Angiotensin II Receptor Blockade: effect and safety in elderly patients with diabetes.
J Card Fail. 2004 Oct;10(5):412-20.
Tanaka H et all.
Losartan improves left ventricular function in patients with hypertension
Regional left ventricular systolic and diastolic function in hypertensive patients can be improved by taking Losartan: precise assessment using a recently developed color-coded tissue doppler imaging technique.
Angiology. 2004 Nov;55(6):669-678.
Zakynthinos E et all.
Critical Care and Pulmonary Services
Losartan Reduces Left Ventricular Hypertrophy Proportionally to Blood Pressure Reduction in Hypertensives, but Does Not Affect Diastolic Cardiac Function.
Left ventricular hypertrophy proportionally to blood pressure reduction in patients with hypertension can be reduced by losartan with out affecting diastolic cardiac function.
Circulation. 2004 Nov 29.
Koh KK et all.
Effects of Losartan With Simvastatin in Hypercholesterolemic, Hypertensive Patients.
Efficacy of Losartan co-administered with simvastatin in the treatment of hypercholesterolemic in patients with hypertension.
Int J Pharm. 2005 Mar 3;291(1-2):127-37. Epub 2004 Dec 28.
Lusina M et all.
Stability study of losartan, hydrochlorothiazide.
A detailed study on the stability of losartan/hydrochlorothiazide tablets.
Hypertens Res. 2004 Dec;27(12):963-70.
Horita Y et all.
Therapy with temocapril and losartan
Proteinuria in normotensive on immunoglobulin a nephropathy patients can be reduced by low-dose combination therapy with temocapril and losartan.
Cardiovasc Diabetol. 2005 May 15;4(1):6
Vitale C et all.
Telmisartan and Losartan in Patients with Metabolic Syndrome.
Use of telmisartan and losartan in patients hypertension and metabolic syndrome and its effects.
Cozaar review article...
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