Coaxil prescribing information |
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Coaxil Description
Coaxil belongs to a group of tricyclic derivatives that acts as an efficient anti depressant as it boosts the absorption of serotonin by the neurons present in the hippocampus and the cerebral cortex. As per the influence of these drugs on mood disorders and swings, Coaxil occupies a special position in between likes of s stimulant and antidepressant. Coaxil is consumed to tackle extreme conditions of depression and somatic symptoms like pain in epigastric region, headache, dizziness, nausea and muscle pain. Coaxil has a huge impact on the behavioural patterns of humans especially on those with problems like chronic alcoholism. One of the best features of Coaxil is that it has no negative influence on human concentration, ability to sleep or even memory.
Description
Coaxil is an antidepressant that is chemically linked to amineptine, which is a kind of serotonin reuptake accelerator and it works exactly opposite to the actions of SSRI’s. Coaxil is also referred by the name of Tianeptine, which is an antidepressant with a novel profile of neurochemical profile. Its main function is to increase the serotonin absorption in brain, which thereby reduces the stress from neuronal dendrites. In comparison to most of the anti depressant agent, Coaxil or tianeptine does not have major side effects on sleep or body weight, which is why Coaxil has a better pharmacokinetic profile.
Side Effects of Coaxil
Similar to anti depressants available in the market, Coaxil also has some side effects that may be unpleasant for some people. Some probable side effects are delineated below:
• Dryness of the mouth
• Gastralgia
• Flatulence insomnia
• Abdominal pain
• Nausea
• Anorexia
• Vomiting
• Drowsiness
• Asthenia tachycardia
• Extrasystole
• Precordialgia dizziness
• Frequent headaches
• Faintness
• Trembling or muscle weakness
• Upsets respiratory discomfort
• Tightness of the throat myalgia
• Lumbago
Caution
Although Coaxil is considered better than other anti-depressant present in the market but there are certain cautions that one should maintain while consuming it. A person should take this medicine under the supervision of a doctor and should consult the doctor again if planning to stop the consumption. The treatment of Coaxil should never be continued if one has to undergo general anaesthetic otherwise, he or she should inform the anaesthetist before the operation. It is advisable to stop the treatment 24 to 48 hours before the surgery or any other medical intervention. If in any case you are planning to stop the treatment of Coaxil then the dosage should be reduced in moderate quantities. Moreover, if the patient is pregnant or even breast-feeding, then one should consult the doctor. As per the medical studies, there should be a gap between the treatments of Coaxil and a MAO. The gap between the two treatments should be at least 15 days. If you are about to expect or pregnant then also one should consult a doctor before starting or stopping Coaxil treatment.
Coaxil notes
Coaxil is the product brand name for the drug that is generally known as Tianeptinum. It is manufactured by a French company named Servier. Coaxil is an effective drug if the patient shows symptoms of depressive disorders and helps in improving the anxiety associated with the ailment. Patients, who are dependent on alcohol, can also benefit from this drug in case they suffer from the symptoms of depression and anxiety.
Coaxil is a drug that needs to be taken according to specified instructions of the doctor and can be taken with food or without it. Also, it is vital that the decision to continue the usage of Coaxil should be taken after proper discussion with the doctor.
Coaxil shares a chemical relation with amineptine and has a unique neurochemical profile. Unlike most other antidepressant drugs, Coaxil helps in raising the consumption of serotonin inside the brain and also decreases the degeneration of neuronal dendrites caused by stress. Also, unlike the other major tricyclic antidepressants and the selective serotonin reuptake inhibitors (SSRIs), the irregular intake of Coaxil does not induce effects like adverse cognitive, psychomotor, sleep, cardiovascular or bodyweight.
However, Coaxil is not entirely free of side effects. Varying from patient to patient, the intake of Coaxil can cause problems like abdominal pain, vomiting, nausea, and trembling etc. Most of these side effects go away with time and are not very severe in nature. In addition, it is not necessary that every patient, who takes Coaxil, will suffer from some side effect.
Finally, as in case of any other medication, if the patient taking Coaxil is to undergo an anesthetic procedure, it is vital to inform the doctor and get the medication stopped. Also pregnant ladies and breast feeding mothers also need to tell their doctor about the same before taking any antidepressant.
Pak J Pharm Sci. 2010 Jul;23(3):266-72.
Bano S, Gitay M, Ara I, Badawy A.
Clinical Biochemistry and Psychopharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan. saminbpk@yahoo.com
[How antidepressants works on metabolism and corticosterone levels] Acute effects of serotonergic antidepressants on tryptophan metabolism and corticosterone levels in rats.
AAPS PharmSciTech. 2010 Jun 8. [Epub ahead of print]
El-Setouhy DA, El-Malak NS.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt, doaaahmed@hotmail.com.
[Tianeptine sodium orodispersible development] Formulation of a Novel Tianeptine Sodium Orodispersible Film.
Hum Exp Toxicol. 2010 May 24. [Epub ahead of print]
Ari M, Oktar S, Duru M.
Department of Psychiatry, Medical Faculty of Mustafa Kemal University, Hatay, Turkey.
[Naloxene leads to poisoning of tianeptine] Amitriptyline and tianeptine poisoning treated by naloxone.
Neuro Endocrinol Lett. 2009;30(5):562-3.
Niederhofer H.
Regional Hospital of Bolzano, Department of Pediatrics, Bolzano, Italy. helmutniederhofer@yahoo.de
[Report depicting the treatment of narcolepsy using tianeptine] Tianeptine treating narcolepsy. Case report.
Modafinil and Methylphenidate are proven to be effective in treating Narcolepsy, but also antidepressants that enhance synaptic levels of noradrenaline and serotonin have been reported as having some therapeutic efficacy. The patient reported in this article received Tianeptine 37.5 mg for two consecutive months. One week after start of treatment improvement of both sleepiness and cataplexy could be noticed. He showed an improvement of the Epworth Sleepiness Scale Score from 22 up to 16.
Bull Exp Biol Med. 2009 Jul;148(1):54-6.
Aleeva GN, Molodavkin GM, Voronina TA.
Laboratory for Creation, Testing, Distribution, Manufacturing, and Marketing of Drugs, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Russia. niipharm@mail.ru
[Study to analyse azafan, tianeptine and paroxetine] Comparison of antidepressant effects of azafan, tianeptine, and paroxetine.
Antidepressant activity of Russian product Azafen (pipofezine) and foreign products Paroxetine and Tianepine was compared using behavioral despair test (Porsolt test) and forced swimming test in a container with wheels (Nomura). Azafen significantly shortened the duration of depressive state in both tests. The results suggest that Azafen exhibits pronounced antidepressant activity, superior to that of the reference drugs.
Pharmacol Rep. 2009 Jul-Aug;61(4):612-20.
Szymańska M, Suska A, Budziszewska B, Jaworska-Feil L, Basta-Kaim A, Leśkiewicz M, Kubera M, Gergont A, Kroczka S, Kaciński M, Lasoń W.
Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland.
[Study which shows how stress decreases glycogen synthase kinase-3 phosphorylation] Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.
Curr Neuropharmacol. 2008 Dec;6(4):311-21.
Zoladz PR, Park CR, Muńoz C, Fleshner M, Diamond DM.
Medical Research Service, VA Hospital, Tampa, Florida, USA.
[Antidepressant tianeptine having memory protective capability] Tianeptine: an antidepressant with memory-protective properties.
Neuropsychopharmacol Hung. 2008 Dec;10(5):305-13.
András S.
Vas Megyei Markusovszky Kórház, Pszichiátriai Centrum. sumegia@gmail.com
Tianeptine proves to be a antidepressive mechanism [
Pharmacol Rep. 2008 Nov-Dec;60(6):1008-13.
Solich J, Pałach P, Budziszewska B, Dziedzicka-Wasylewska M.
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. solich@if-pan.krakow.pl
[Study showing the circumstances raised due to the lack of noradrenaline transporter] Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
Eur J Neurosci. 2007 Dec;26(12):3509-17.
Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P.
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA.
[References and actions of tianeptine] Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine.
J AOAC Int. 2007 May-Jun;90(3):720-4.
Ulu ST.
University of Istanbul, Faculty of Pharmacy, Department of Analytical Chemistry, 34452, Istanbul, Turkey.
[Performance of tianeptine when given in the form of tablets] Determination of tianeptine in tablets by high-performance liquid chromatography with fluorescence detection.
Gynecol Endocrinol. 2007 May;23(5):267-72.
Filho RB, Domingues L, Naves L, Ferraz E, Alves A, Casulari LA.
Endocrinology and Neurology Clinics - CLINEN, Brasília, Brazil.
[Difference between polycystic ovary syndrome and hyperprolactinemia] Polycystic ovary syndrome and hyperprolactinemia are distinct entities.
Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(11):24-9.
Aleksandrovskii IuA, Avedisova AS, Boev IV, Bukhanovkskii AO, Voloshin VM, Tsygankov BD, Shamrei BK.
Efficacy and tolerability of coaxil (tianeptine) in the therapy of posttraumatic stress disorder [Article in Russian]
Treatment of posttraumatic stress disorder using of coaxil (tianeptine) and its efficacy and tolerability.
The results of a multicenter study of coaxil in the treatment of 90 patients with posttraumatic stress disorder (PTSD) are summarized. Two dosages of the drug, 75 mg daily (44 patients) and 37.5 mg daily (46 patients) have been compared. Coaxil efficacy was estimated with the Clinician Administered PTSD Scale (CAPS) and Hamilton depression scale (HAM-D). High efficacy of coaxil was shown, with 76.7 and 75.6% responders, respectively, for the dosages used. The optimum one proved to be 37.5 mg daily, which is congruent to the standard dose in the treatment of depression and provides not only the efficacy but tolerability of coaxil. The coaxil efficacy depended on a PTSD type: the drug was more effective in chronic PTSD that, in the authors' opinion, might be related to its antidepressant action.
Ter Arkh. 2006;78(4):38-44
Chazov EI et all.
Depression in cardiological practice
Depression in cardiac patients with ischemic heart disease: a pilot results from a multicenter clinico-epidemiological trial in hypertensive patients.
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(10):47-51.
Kochetkov IaA et all.
Anabolic-catabolic balance. Effect of coaxil
Efficacy of coaxil in anabolic and catabolic balance in depression achieve changes (stress reaction).
Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106(3):20-5.
Levin OS.
Coaxil (tianeptine) in the treatment of depression in Parkinson's disease [Article in Russian]
Treatment using Coaxil (tianeptine) for depression in patients with Parkinson's disease.
Coaxil review article...
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