Adalat Review Article |
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 Adalat (generic name: nifedipine) is a dihydropyridine calcium channel blocker. It is primarily used as an antihypertensive and antianginal (especially in the case of Prinzmetal’s angina). Recently, a wide array of other uses of this drug has been discovered, such as premature labor, Raynaud’s phenomenon, and painful contractions of the esophagus in tetanus and cancer patients. It is also widely used for a small division of pulmonary hypertension patients with symptoms responding to calcium channel blockers.
Adalat is classified as a dihydropyridine calcium channel blocker used as an antianginal for conditions such as Prinzmetal’s angine as well as a antihypertensive. After some recent time, it has also been experimentally prescribed with premature labor, Raynaud’s phenomenon and muscle spasms as exhibited with esophageal cancer or tetanus. On some cases, doctors prescribe Adalat to be used for pulmonary hypertension which affects respiratory capacity. The continued use is determined through any observable improvements in breathing or elimination of dizziness and other associated symptoms.
According to a Stanford study regarding Nifedipine, preterm labor was prevented due to the administration of Adalat to pregnant females ages 18 and above. This entailed no occurrence of delivery or absence of any signs of delivery after 48 hours of administration of the drug orally. It was also administered along with magnesium sulfate intravenously. The researchers determined both as an effective therapy for acute tocolysis of preterm labor. There was also a result of uterine quiescence Continue reading...
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Adalat has also been compared to other antihypertensive drugs such as Coracten. The patients were medicated with one of the two drugs on the first 2 weeks and were then switched afterwards for the alternative drug on the next 2 weeks. After this, they were prescribed with the initial drug only in a 1 day period. Baseline data and periodic examinations included blood samples, blood pressure and heart rate throughout the study. According to the results gathered from participants on an 18 to 75 year age group from both genders with mild to moderate hypertension, Adalat served as a better maintenance as proven by data from other similar studies but difference between the two are still minimal to be considered conclusive.
Other experimental uses of Adalat includes as a topical cream for Vulvar Vestibulitis. There were 30 18 to 45 year old women who participated in the study. Each were correctly diagnosed with Vulvodynia. The group was separated into three with one on 0.2% Nifedipine cream, the following on 0.4% and the last as a placebo control group. They applied the cream 4 times a day for a duration of 3 months except on menstrual period which only totaled to 6 weeks of treatment. After this period, they were examined with Q-tip tests and compared to that of the start. Dyspareunia, which was pain during sexual intercourse and an associated symptom, was lessened and even eliminated for some of the participants. Researchers plan to perform the trial on a larger study group for more concrete results.
Reference:
1. Stanford University (Sponsor). 2005.Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial.
2. Bayer (Sponsor). 2008. Effects of Adalat LA and Coracten on Drug Levels, Blood Pressure, and Heart Rate in Fed Patients With Hypertension.
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 Adalat Review Article
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