Acarbose prescribing information |
|
 |
|
We offer 10% discount!
Acarbose description
Indication:
Acarbose is prescribed to help lower blood sugar levels that is an alpha-glucoside inhibitor obtained from the fermentation of process of microorganism which delays the digestion of ingested carbohydrates. It does not enhance insulin secretion and can be used alone to treat type II diabetes. It's effect are additive to those of the sulfonylurea in controlling blood glucose.
Mechanism of action:
Acarbose competitively and reversibly inhibits pancreatic á-amylase and intestinal brush border á-glucosidases, resulting in retardation of glucose absorption from hydrolysed complex carbohydrates and reduction of blood-glucose concentrations.
Dosage and Administration:
Initially it is given at 25mg daily. Dose is adjusted at 4 to 8 wkly intervals based on tolerance and 1 hr postprandial glucose levels. Give three times at the start of each meal.
For patients with severe kidney dysfunction or liver disease smaller doses may be given. It should not be given to patient with certain medical condition such as inflammatory bowel disease, intestinal obstruction, and chronic intestinal disease cause it interferes with digestion and absorption.
Drug Interactions:
Possible decrease in digoxin levels if combined, monitor patients closely if this combination is used. Decreased effects of acarbose if taken with digestive enzymes or charcoal; avoid these combination.
In combination with sulfonylurea, blood glucose may be much lower; monitor closely and adjust dosages of each drug accordingly.
Pregnancy:
It is set as a Category B by the US Food and Drug Administration which indicates that no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect.
Nursing Mothers:
It has found out that acarbose is excreted in milk by lactating animals. No human studies was conducted. Breastfeeding mother should talk to their doctor first before taking the drug.
Interaction with Alcohol:
As to its interaction with alcohol,it does increase blood sugar. It would be better to seek medical advice.
Adverse/Side effects:
Certain side effects may occur such as abdominal pain, flatulence, and bloating.Report unusual bleeding or bruising( symptoms of decrease hematocrit) and severe abdominal pain because its rare side effect can affect liver enzymes,calcium, or Vitamin B6 levels.
Storage:
This drug should be stored in a tightly close container, away from heat and moisture, and stored at room temperature. Should be placed out of reach of children.
2010 Apr;19(106):68-70.
Inclusive of drugs involvement : Digoxin
2010 Apr 23. [Epub ahead of print]
Introduction of unique technique for patients diagnosed with insulin resistance
2009 Dec 23;57(24):11463-8.
Assessing quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase
2009 Oct;9(5):355-9.
The alternatives for manipulating prandial glycemia
2009;59(11):557-63.
Impact of acarbose on our bodily changes due to carbohydrate load with sucrose or starch
2008 Oct 20;121(20):2054-9.
Prevention and securing effects of acarbose in treating postprandial hypotension
2008 Nov;4(4):340-56.
Pharmaceutical help for diabetic and obese patients with postprandial lipid metabolism
2008 Jun 27. [Epub ahead of print]
Blessing in disguise : Antidiabetic Indian Plants
2007 Oct;7(5):333-9.
Beneficiary of alpha-glucosidase inhibitors
Diabet Med. 2007 Mar 22;
Digestion of starch will not be interrupted due to the usage of low-dose acarbose, but bioavailability shall be reduced
Fertil Steril. 2007 Apr 5
Low dose of acarbose reduces the cardiovascular risk factors in obese patients with polycystic ovary syndrome
Orv Hetil. 2006 Aug 6;147(31):1443-6.
Find out the most effective ways to reduce cardiovascular risk in type 2 diabetes mellitus patients
Diabetes Metab. 2002 Jun;28(3):195-200.
Insulin resistance and secretion will be improved indirectly by acarbose in obese type 2 diabetic patients
Clin Ther. 1997 Jul-Aug;19(4):720-9.
Compare the effects of acarbose and voglibose in health related matters
Med Klin. 1998 Nov 15;93(11):651-5.
Monitor the blood glucose in a periodic basis to find out the effect of acarbose on blood glucose variations
Diabetes Nutr Metab. 1999 Aug;12(4):277-85.
A multicentre, double-blind, placebo-controlled study for 2-year on the effects of acarbose treatment in Type 2 diabetic patients under dietary training
Diabetes Obes Metab. 2000 Jan;2(1):33-8.
Use of acarbose in the treatment of familial hypertriglyceridaemia
Eat Weight Disord. 1998 Mar;3(1):46-9.
A controlled study on Acarbose treatment for obesity
J Gerontol A Biol Sci Med Sci. 2002 Feb;57(2):M111-4.
How acarbose affect on the colonic transit time of elderly long-term care patients with type 2 diabetes mellitus?
Diabetes Res Clin Pract. 2003 Jan;59(1):37-42.
Treatment using acarbose in elderly patients with type 2 diabetes
JAMA. 2003 Jul 23;290(4):486-94.
Treatment using acarbose in patients with impaired glucose tolerance and the risk of cardiovascular disease and hypertension: the STOP-NIDDM trial
Diabetes Obes Metab. 2001 Dec;3(6):423-7.
How acarbose affect on weight maintenance after dietary weight loss in obese subjects?
Diabetes Obes Metab. 2003 Jan;5(1):38-44.
Acarbose or glibenclamide treatment on type 2 diabetic patients with insulin sensitivity.
Diabetes Care. 2005 Mar;28(3):736-44.
Delay or prevent type 2 diabetes by a regular review of drug therapy
Acarbose review article...
|
My Basket
